93 research outputs found
Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis
<p>Abstract</p> <p>Background</p> <p>Various angiogenic regulators are involved in angiogenesis cascade. Transcription factor Ets-1 plays important role in angiogenesis, remodeling of extracellular matrix, and tumor metastasis. Ets-1 target genes involved in various stages of new blood vessel formation include angiopoietin, matrix metalloproteinases (MMPs) and the protease inhibitor maspin.</p> <p>Methods</p> <p>We used immunohistochemistry (IHC) to detect the expression of Ets-1, angiopoietin-2 (Ang-2) and maspin in ovarian tumor and analyzed the relationship between the expression of these proteins and the clinical manifestation of ovarian cancer.</p> <p>Results</p> <p>Ets-1 expression was much stronger in ovarian cancer compared to benign tumors, but had no significant correlation with other pathological parameters of ovarian cancer. However, Ang-2 and maspin expression had no obvious correlation with pathological parameters of ovarian cancer. Ets-1 had a positive correlation with Ang-2 which showed their close relationship in angiogenesis. Although microvessel density (MVD) value had no significant correlation with the expression of Ets-1, Ang-2 or maspin, strong nuclear expression of maspin appeared to be correlated with high grade and MVD.</p> <p>Conclusions</p> <p>The expression of Ets-1, Ang2 and maspin showed close relationship with angiogenesis in ovarian cancer and expression of maspin appeared to be correlated with high grade and MVD. The mechanisms underlying the cross-talk of the three factors need further investigations.</p
Tell Me How to Survey: Literature Review Made Simple with Automatic Reading Path Generation
Recent years have witnessed the dramatic growth of paper volumes with plenty
of new research papers published every day, especially in the area of computer
science. How to glean papers worth reading from the massive literature to do a
quick survey or keep up with the latest advancement about a specific research
topic has become a challenging task. Existing academic search engines such as
Google Scholar return relevant papers by individually calculating the relevance
between each paper and query. However, such systems usually omit the
prerequisite chains of a research topic and cannot form a meaningful reading
path. In this paper, we introduce a new task named Reading Path Generation
(RPG) which aims at automatically producing a path of papers to read for a
given query. To serve as a research benchmark, we further propose SurveyBank, a
dataset consisting of large quantities of survey papers in the field of
computer science as well as their citation relationships. Each survey paper
contains key phrases extracted from its title and multi-level reading lists
inferred from its references. Furthermore, we propose a
graph-optimization-based approach for reading path generation which takes the
relationship between papers into account. Extensive evaluations demonstrate
that our approach outperforms other baselines. A Real-time Reading Path
Generation System (RePaGer) has been also implemented with our designed model.
To the best of our knowledge, we are the first to target this important
research problem. Our source code of RePaGer system and SurveyBank dataset can
be found on here.Comment: 16 pages, 12 figure
Controllable Multi-Objective Re-ranking with Policy Hypernetworks
Multi-stage ranking pipelines have become widely used strategies in modern
recommender systems, where the final stage aims to return a ranked list of
items that balances a number of requirements such as user preference,
diversity, novelty etc. Linear scalarization is arguably the most widely used
technique to merge multiple requirements into one optimization objective, by
summing up the requirements with certain preference weights. Existing
final-stage ranking methods often adopt a static model where the preference
weights are determined during offline training and kept unchanged during online
serving. Whenever a modification of the preference weights is needed, the model
has to be re-trained, which is time and resources inefficient. Meanwhile, the
most appropriate weights may vary greatly for different groups of targeting
users or at different time periods (e.g., during holiday promotions). In this
paper, we propose a framework called controllable multi-objective re-ranking
(CMR) which incorporates a hypernetwork to generate parameters for a re-ranking
model according to different preference weights. In this way, CMR is enabled to
adapt the preference weights according to the environment changes in an online
manner, without retraining the models. Moreover, we classify practical
business-oriented tasks into four main categories and seamlessly incorporate
them in a new proposed re-ranking model based on an Actor-Evaluator framework,
which serves as a reliable real-world testbed for CMR. Offline experiments
based on the dataset collected from Taobao App showed that CMR improved several
popular re-ranking models by using them as underlying models. Online A/B tests
also demonstrated the effectiveness and trustworthiness of CMR
Association between admission-blood-glucose-to-albumin ratio and clinical outcomes in patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention
IntroductionIt is unclear whether admission-blood-glucose-to-albumin ratio (AAR) predicts adverse clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) who are treated with percutaneous coronary intervention (PCI). Here, we performed a observational study to explore the predictive value of AAR on clinical outcomes.MethodsPatients diagnosed with STEMI who underwent PCI between January 2010 and February 2020 were enrolled in the study. The patients were classified into three groups according to AAR tertile. The primary outcome was in-hospital all-cause mortality, and the secondary outcomes were in-hospital major adverse cardiac events (MACEs), as well as all-cause mortality and MACEs during follow-up. Logistic regression, Kaplan–Meier analysis, and Cox proportional hazard regression were the primary analyses used to estimate outcomes.ResultsAmong the 3,224 enrolled patients, there were 130 cases of in-hospital all-cause mortality (3.9%) and 181 patients (5.4%) experienced MACEs. After adjustment for covariates, multivariate analysis demonstrated that an increase in AAR was associated with an increased risk of in-hospital all-cause mortality [adjusted odds ratio (OR): 2.72, 95% CI: 1.47–5.03, P = 0.001] and MACEs (adjusted OR: 1.91, 95% CI: 1.18–3.10, P = 0.009), as well as long-term all-cause mortality [adjusted hazard ratio (HR): 1.64, 95% CI: 1.19–2.28, P = 0.003] and MACEs (adjusted HR: 1.58, 95% CI: 1.16–2.14, P = 0.003). Receiver operating characteristic (ROC) curve analysis indicated that AAR was an accurate predictor of in-hospital all-cause mortality (AUC = 0.718, 95% CI: 0.675–0.761) and MACEs (AUC = 0.672, 95% CI: 0.631–0.712).DiscussionAAR is a novel and convenient independent predictor of all-cause mortality and MACEs, both in-hospital and long-term, for STEMI patients receiving PCI
Efficient current-induced spin torques and field-free magnetization switching in a room-temperature van der Waals magnet
The discovery of magnetism in van der Waals (vdW) materials has established
unique building blocks for the research of emergent spintronic phenomena. In
particular, owing to their intrinsically clean surface without dangling bonds,
the vdW magnets hold the potential to construct a superior interface that
allows for efficient electrical manipulation of magnetism. Despite several
attempts in this direction, it usually requires a cryogenic condition and the
assistance of external magnetic fields, which is detrimental to the real
application. Here, we fabricate heterostructures based on Fe3GaTe2 flakes that
possess room-temperature ferromagnetism with excellent perpendicular magnetic
anisotropy. The current-driven non-reciprocal modulation of coercive fields
reveals a high spin-torque efficiency in the Fe3GaTe2/Pt heterostructures,
which further leads to a full magnetization switching by current. Moreover, we
demonstrate the field-free magnetization switching resulting from out-of-plane
polarized spin currents by asymmetric geometry design. Our work could expedite
the development of efficient vdW spintronic logic, memory and neuromorphic
computing devices
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